Project MAC’s SYmbolic MAnipulator is a programming language created in 1968.
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Macsyma (Project MAC’s SYmbolic MAnipulator) is one of the oldest general purpose computer algebra systems which is still widely used. It was originally developed from 1968 to 1982 at MIT's Project MAC. In 1982, Macsyma was licensed to Symbolics and became a commercial product. Read more on Wikipedia...